HER2/HER3 and PIK3CA Mutations in Colorectal Cancer are Associated with Microsatellite Instability

By Anthony M Magliocco MD

 

top-10-reasons-to-ask-your-doctor-about-colon-cancer-screening-1080x675

 

A recent study by Loree reported in the  Journal of the National Cancer Institute, found that ERBB2/ERBB3 mutations in colorectal cancer are associated with the presence of MSI microsatellite instability and PIK3CA mutation.

Study Details- Retrospective analysis of Colorectal Cancer Cases from two Cohorts

The study involved retrospective analysis of 419 patients from The University of Texas MD Anderson Cancer Center (MDACC) and 619 patients from the Nurses’ Health Study (NHS)/Health Professionals Follow-Up Study (HPFS) with stage I to IV disease, with tissue sequencing, clinicopathologic, mutational, and colorectal cancer consensus molecular subtype (CMS) profiles of patients with ERBB2/ERBB3 mutations. The circulating tumor DNA profile associated with ERBB2mutation was also investigated in an additional cohort of 1,623 patients with circulating tumor DNA assay results.

epithelial-cell-in-metaphase

Factors Associated With ERBB2/ERBB3 Mutation

Mutations were found in over 5% of cases and were not associated with age, location or stage of tumor. ERBB2 mutations were associated with shortend survival HR 1.82 but not ERBB3

The investigators concluded, “[Microsatellite instability] and PIK3CA mutations are associated with ERBB2/ERBB3 mutations. Co-occurring PIK3CA mutations may represent a second hit to oncogenic signaling that needs consideration when targeting ERBB2/ERBB3.”

 

The findings are interesting in that mutated ERBB2 is potentially an actionable target.

11 thoughts on “HER2/HER3 and PIK3CA Mutations in Colorectal Cancer are Associated with Microsatellite Instability

  1. Hello there! This is kind of off topic but I need some guidance from an established blog.
    Is it very difficult to set up your own blog?
    I’m not very techincal but I can figure things out pretty fast.
    I’m thinking about creating my own but I’m not sure where to begin. Do you have any tips or suggestions?
    Many thanks http://ultraketo550.net/

  2. We stumbled over here by a different web page and thought I might
    as well check things out. I like what I see so now i am following you.
    Look forward to checking out your web page for a second time.

  3. Hello there! This blog post couldn’t be written much better!
    Reading through this article reminds me of my
    previous roommate! He continually kept talking about this.
    I am going to send this post to him. Fairly certain he’ll have a great read.

    Thank you for sharing! https://crwl.it/188bet461541

Leave a Reply

Your email address will not be published. Required fields are marked *